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Former IAS Senior Fellow / Fellow

Prof Mingjie ZHANG

Adjunct Professor of Life Science, HKUST

Prof. Mingjie Zhang received his PhD in Biochemistry from the University of Calgary in 1993. He worked as a postdoctoral fellow at the National Cancer Institute of Canada before joining HKUST in 1995. He had spent 25 years at HKUST and was appointed Chair Professor of the Division of Life Science and Kerry Holdings Professor of Science. In 2020, he moved to the Southern University of Science and Technology to take up the role of Dean of Life Sciences while he is still affiliated with HKUST as an Adjunct Professor of Life Science to continue the collaborations with IAS HKUST - Scripps R&D Lab.

Prof. Zhang's research focuses on molecular mechanisms of organization and regulation of neuronal signaling complexes and machineries in controlling cell polarity by using protein crystallography and NMR spectroscopy. He has published extensively in the leading journals including Science, Nature Structural Biology/Nature Structural & Molecular Biology, EMBO Journal, etc.

In 2002, he won the Outstanding Overseas Young Scientist Award by the National Natural Science Foundation of China, followed by the Croucher Senior Research Fellowship in 2003. He also snagged the Second Prize of the State Natural Science Award in 2006 and the Ho Leung Ho Lee Foundation Science and Technology Advancement Award in mid-2011. He has served as an Advisor on the Overseas Scientific Evaluation Committee of the Chinese Academy of Sciences, as well as Reviewer, Editorial Board Member and Director to a number of international journals and academic institutions. He is also a founding member of The Hong Kong Academy of Sciences. He was elected to the Chinese Academy of Sciences in 2011.

+ News / Interviews with IAS byline (Total: 17 records)

+ Research publications with IAS byline (Total: 26 records)

Publications	View / Download
Xu, Z., Lo, W., Beck, D., Schuch, L., Oláhová, M., Kopajtich, R., Chong, Y., Alston, C., Seidl, E., Zhai, L., Lau, C., Timchak, D., LeDuc, C., Borczuk, A., Teich, A., Juusola, J., Sofeso, C., Müller, C., Pierre, G., Hilliard, T., Turnpenny, P., Wagner, M., Kappler, M., Brasch, F., Bouffard, J., Nangle, L., Yang, X., Zhang, M., Taylor, R., Prokisch, H., Griese, M., Chung, W. and Schimmel, P. (2018). Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function. The American Journal of Human Genetics, 103(1), pp.100-114.
Li, J., He, Y., Weck, M., Lu, Q., Tyska, M. and Zhang, M. (2017). Structure of Myo7b/USH1C Complex Suggests a General PDZ Domain Binding Mode by MyTH4-FERM Myosins. Proceedings of the National Academy of Sciences, 114(19), pp.E3776-E3785. doi:10.1073/pnas.1702251114
Li, J., Chen, Y., Deng, Y., Unarta, I., Lu, Q., Huang, X. and Zhang, M. (2017). Ca 2+ -Induced Rigidity Change of the Myosin VIIa IQ Motif-Single α Helix Lever Arm Extension. Structure, 25(4), pp.579-591.e4. doi:10.1016/j.str.2017.02.002
Pedersen, S., Albertsen, L., Moran, G., Levesque, B., Pedersen, S., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., Bowen, M. and Strømgaard, K. (2017). Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions. ACS Chemical Biology, 12(9), pp.2313-2323. doi:10.1021/acschembio.7b00361
Ye, F., Liu, W., Shang, Y. and Zhang, M. (2016). An Exquisitely Specific PDZ/Target Recognition Revealed by the Structure of INAD PDZ3 in Complex with TRP Channel Tail. Structure, 24(3), pp.383-391. doi:10.1016/j.str.2015.12.013
Wei, Z., Xu, Z., Liu, X., Lo, W., Ye, F., Lau, C., Wang, F., Zhou, J., Nangle, L., Yang, X., Zhang, M. and Schimmel, P. (2016). Alternative Splicing Creates Two New Architectures for Human Tyrosyl-tRNA Synthetase. Nucleic Acids Research, 44(3), pp.1247-1255. doi:10.1093/nar/gkw002
Lorenzo, D., Healy, J., Hostettler, J., Davis, J., Yang, J., Wang, C., Hohmeier, H., Zhang, M. and Bennett, V. (2015). Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. Journal of Clinical Investigation, 125(8), pp.3087-3102. doi:10.1172/JCI81317.
Wei, Z., Li, Y., Ye, F. and Zhang, M. (2015). Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin. Journal of Biological Chemistry, 290(18), pp.11384-11392. doi:10.1074/jbc.m115.643791
Lu, Q., Li, J. C., Ye, F., Zhang, M. J. (2015). Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nature Structural & Molecular Biology, 22(1). doi: 10.1038/nsmb.2923
Lo, W. S., Gardiner, E., Xu, Z. W., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., Guo, M., Zhang, M. J., & Schimmel, P. (2014). Human tRNA synthetase atalytic nulls with diverse functions. Science, 345(6194), 328-332.doi:10.1126/science.1252943
Zhou, J. J., Wang, F., Xu, Z. W., Lo, W. S., Lau, C. F., Chinag, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M. J., & Schimmel, P. (2014). Secreted histidyl-trna synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis. The Journal of Biological Chemistry, 289(28), 19269-19275. doi:10.1074/jbc.C114.571026
Chen, J., & Zhang, M. J. (2013). The Par3/Par6/aPKC complex and epithelial cell polarity. Experimental Cell Research, 319(10), 1357-1364. doi:10.1016/j.yexcr.2013.03.021
Pan, Z., Shang, Y., Zhang, L., Xia, C. H., Zhang, M. J., Wang, W. N., & Wen, W. Y. (2013). Structural and biochemical characterization of the interaction between LGN and Frmpd1. Journal of Molecular Biology, 425(6), 1039-1049. doi:10.1016/j.jmb.2013.01.003
Wei, Z. Y., Liu, X. T., Yu, C., & Zhang, M. J. (2013). Structural basis of cargo recognitions for class V myosins. Proceedings of the National Academy of Science of the United States of America, 110(28), 11314-11319. doi:10.1073/pnas.1306768110
Pan, Z., Zhu, J. W., Shang, Y., Wei, Z. Y., Jia, M., Xia, C. H., Wen, W. Y., Wang, W. N., & Zhang, M. J. (2013). An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco Motifs and TPR Motifs. Structure, 21(6), 1007-1017. doi:10.1016/j.str.2013.04.005
Ye, F., & Zhang, M. J. (2013). Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures. Biochemical Journal, 445, 1-14. doi:10.1042/BJ20130783
Wei, Z. Y., & Zhang, M. J. (2013). Decorating proteins with "sweets" is a flexible matter. Structure, 21(1), 1-2. doi:10.1016/j.str.2012.12.004
Wang, F. , Xu, Z. W. , Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M. J., & Schimmel, P. (2013). Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases. The Journal of Biological Chemistry, 288(41), 29223-29228. doi:10.1074/jbc.C113.490599
Chen, S., Chen, J., Shi, H., Wei, M., Castaneda-Castellanos, D. R., Bultje, R. S., Pei, X., Kriegstein, A. R., Zhang, M. J., & Shi, S. H. (2013). Regulation of microtubule stability and organization by mammalian par3 in specifying neuronal polarity. Developmental Cell, 24(1), 26-40. doi:10.1016/j.devcel.2012.11.014
Lu, Q., Ye, F., Wei, Z. Y., Wen, Z. L., & Zhang, M. J.(2012). Antiparallel coiled-coil-mediated dimerization of myosin X. Proceedings of the National Academy of Science of the United States of America, 109(43), 17388-17393. doiL 10.1073/pnas.1208642109
Wang, C. H., Shang, Y., Yu, J. & Zhang, M. J. (2012). Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCl in complex with a substrate peptide from Par-3. Structure, 20(5), 791-801. doi:10.1016/j.str.2012.02.022
Yu, C., Loi, J. H., Wu, J. J., Pan, L. F., Feng, W., & Zhang, M. J.(2012). Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes. The Journal of Biological Chemistry, 287(42), 35021-35035. doi:10.1074-jbc.M111.328781
Wu, L., Pan, L. F., Zhang, C. C., & Zhang, M. J. (2012). Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. The Journal of Biological Chemistry, 287(40), 33460-33471. doi:10.1074/jbc.M1123.378505
Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S. ,Wang, F. , Lau, C. F., Wu, J. J., Nangie, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., & Schimmel, P. (2012). Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Structure, 20(9), 1470-1477. doi:10.1016/j.str.2012.08.001
Wei, Z. Y., Yan, J., Lu, Q., Pan, L. F., & Zhang, M. J. (2011). Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. Proceedings of the National Academy of Science of the United States of America, 108(9), 3572-3577. doi:10.1073/pnas.1016567108
Wei, Z. Y., Zheng, S. L., Spangler, S. A., Hoogenraad, C. C., & Zhang, M. J. (2011). Liprin-mediated large signaling complex organization revealed by the Liprin-α/CASK and Liprin-α/Liprin-βcomplex structures. Molecular Cell, 43(4), 586-598. doi:10.1016/j.molcel.2011.07.021

+ Engagement in IAS activities / events (Total: 1 record)

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The New IAS Website https://ias.hkust.edu.hk/ is launched.

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