Proteomics is the large-scale identification and quantification of proteins in complex biological matrices, such as blood, bodily fluids, cells and extracts. Today proteomics is performed by a combination of liquid chromatography and tandem mass spectrometry (LC-MS/MS). The area of proteomics application is vast. In this lecture, recent advances in some important fields of proteomics will be discussed. For disease diagnostics, the SpotLight proteomics approach has been developed in which the repertoire of human antibodies in individuals is sequenced and specific sequences are correlated to certain diseases. In drug development, chemical proteomics has been redefined to signify the use of proteomics to determining the target, binding site and mechanism of action of small molecules. In chemical proteomics, a number of novel tools have been developed, including the TargetMiner, a database of late-apoptosis proteomics signatures of dozens of anticancer agents. These tools may provide valuable help in developing new and more efficient anticancer drugs.
About the speaker
Prof Roman Zubarev received his PhD in Ion Physics from Uppsala University in 1997. After completing his postdoctoral training in Cornell University, he became an associate professor in Biological Mass Spectrometry in Odense University (which later became the University of Southern Denmark). In 2002, Prof Zubarev returned to Uppsala University as a professor of proteomics. He then moved to Karolinska Institutet in 2009 and is currently a professor there.
Prof Zubarev’s research focuses on Molecular Biometry using mass spectrometry for studying various processes of biological and medical importance. He received numerous awards including the Biemann Medal by the American Society for Mass Spectrometry (2007) and the Curt Brunnée Award by the International Mass Spectrometry Foundation (2006).
For attendees’ attention
The lecture is free and open to all. Seating is on a first come, first served basis.
