Abstract
Physics-based simulations are a powerful approach for investigating the time-varying behavior of protein systems at high spatial and temporal resolution. However, they can be prohibitively time-consuming, especially for probing protein long-timescale behaviors. On the other hand, not all questions about proteins require high space and time resolution to produce informative answers. For instance, by avoiding the simulation of uncorrelated, high-frequency atomic movements, a domain-level picture of protein kinetics and dynamics can be revealed. This talk will highlight a growing body of complementary methods to quickly compute useful information about the long-timescale behavior of a protein without explicit simulation. This seminar is part of HKUST Computational Structural Biology Workshop.
About the speaker
Prof Jean-Claude Latombe received his PhD in Computer Science from the National Polytechnic Institute of Grenoble in 1977. He joined Stanford University in 1987, where he served as Chairman of the Computer Science Department from 1997 to 2000. In 1987-1996, and 2001-2003, he was the Director of the Robotics Laboratory. In 2002-2004 he served on the Steering Committee that led to the creation of the Bio-X program, the largest Stanford inter-disciplinary program centered on Biology. He is currently the Kumagai Professor of Computer Science at Stanford University.
Prof Latombe’s main research interests are in Robotics, Artificial Intelligence, Geometric Computing, and Computational Biology. With students and postdocs, he pioneered the Probabilistic Roadmap approach to motion planning, which is now the method of choice used by many labs and companies around the world. He also pioneered the application of motion planning methods to new areas, such as graphic animation, surgical treatment planning, study of protein folding and binding, and architectural design.
Prof Latombe is the author of the most widely used book on “Motion Planning”. He has authored and co-authored more than 300 publications in journals and international conferences. He was the recipient of the Kwan Im Thong Hood Cho Temple Visiting Professorship at the National University of Singapore in 2004 and 2006. He is a Fellow of the Association for the Advancement of Artificial Intelligence (AAAI) and an Honorary Member of the French Association for Artificial Intelligence (AFIA). Since 2009, he has been a member of the French High Council for Science and Technology, a 20-member committee appointed by French President to advise his government on scientific and technological issues.
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