Abstract
During the lecture, the speaker will present a new technology recently developed in his lab, called GRID-seq, which enables global mapping of RNA-chromatin interactions. In human, mouse and Drosophila cells, the speaker and his research group detected a large set of tissue-specific coding and non-coding RNAs that are bound to active promoters and enhancers, especially super-enhancers, leading to the construction of a functional connectivity map of promoters and enhancers in 3D genome.
About the speaker
Prof Xiang-Dong Fu received his MS in Virology from Wuhan University in 1982 and PhD in Biochemistry from Case Western Reserve University in 1988. He then started his postdoctoral training at Harvard University from 1988 to 1992. He joined the University of California at San Diego in 1992. He is currently the Professor of Cellular and Molecular Medicine.
Prof Fu’s laboratory is interested in molecular and cell biology of RNA metabolism and regulation in higher eukaryotic cells. The current focuses include the regulation of alternative splicing, functional RNA elements in mammalian genomes, transcription/splicing coupling, nuclear architecture and cellular reprogramming.
Prof Fu’s contributions to biomedical science have been recognized by numerous awards. He was an elected fellow of American Association for the Advancement of Science (2010). He was selected a Leukemia and Lymphoma Society Scholar (1997) and a Searle Scholar (1994).
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