Abstract
Several key advances of the past two decades in catalytic olefin metathesis have been transformative. In this lecture, the origins of the inception of various types of catalysts that can be used in kinetically controlled Z- as well as E-selective cross-metathesis and macrocyclic ring-closing metathesis reactions will be analyzed. This will include recent applications to stereoselective synthesis of trisubstituted alkenes. The influence of the recently introduced catalytic protocols on the design of synthesis routes leading to complex organic molecules, and the impact of a better understanding of the mechanistic nuances towards development of more efficient catalytic processes, will be discussed.
About the speaker
Prof Amir H Hoveyda received his bachelor degree from Columbia University in 1981 and his PhD from Yale University in 1986. He joined Harvard University as a Postdoctoral Fellow during 1986-1987 and 1988-1990. He then joined Boston College as Assistant Professor in 1990 and became a Professor in 1994. He has been the Patricia and Joseph T. ’49 Vanderslice Millennium Professor of Chemistry since 1998.
Prof Hoveyda studies organometallic chemistry, particularly in the area of controlled olefin metathesis and asymmetric catalysis. A prolific researcher, he has more than 30 review articles and more than 240 research publications. Holding 15 US patents, he has been affiliated with a number of corporations providing technology solutions. Besides, he was the editorial member of Chemical Communications during 2003-2012 and of Synthesis during 1998-2008.
Prof Hoveyda’s research has been recognized by a number of honors, including the Award for Creative Work in Organic Synthesis from the American Chemical Society (ACS) (2014), the Yamada-Koga Prize from the Japanese Society for Pharmaceutical Sciences (2010), the Merit Award from the US National Institutes of Health (2005), the Cope Scholar Award from the ACS (1998) and the Pfizer Research Award in Synthetic Organic Chemistry (1993).
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