Abstract
A multiscale theoretical and computational methodology will be presented for studying biomolecular systems across multiple length and time scales. The approach provides a systematic connection between all-atom molecular dynamics, coarse-grained modeling, and mesoscopic phenomena. At the heart of the approach is a method for deriving coarse-grained models from protein structures and their underlying molecular-scale interactions. A critical component of the modeling is also its connection to experimental structural data such as cryo-EM or x-ray, thus making it “hybrid” in its character. Recent applications of the overall multiscale approach to describe protein-mediated membrane remodeling as well as large multi-protein complexes such as actin filaments and the HIV-1 virion will be presented.
About the speaker
Prof Gregory A. Voth received his BS in Chemistry from University of Kansas in 1981 and PhD in Theoretical Chemistry from California Institute of Technology in 1987. He joined the University of Pennsylvania as an Assistant Professor in 1989 and moved to University of Utah as the Distinguished Professor of Chemistry in 1997. In 2010, he joined the University of Chicago and is currently the Haig P. Papazian Distinguished Service Professor.
Prof Voth’s research focuses on the theoretical and computer simulation studies of biomolecular and liquid state phenomena, as well as of novel materials. A primary goal of this effort is the development and application of new computational methodologies to explain and predict the behavior of complex systems.
Prof Voth received numerous awards including the US National Science Foundation Presidential Young Investigator Award, US National Science Foundation Creativity Award and the University of Utah Distinguished Scholarly and Creative Research Award. He was also elected the American Physical Society Fellow, the American Association for the Advancement of Science Fellow, the American Chemical Society (Inaugural Class) Fellow, the Biophysical Society Fellow and the International Academy of Quantum Molecular Science Fellow.
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For attendees’ attention
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The lecture is free and open to all. Seating is on a first come, first served basis. |
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Light refreshments will be served from 4:00 to 4:30 pm. |
HKUST Jockey Club Institute for Advanced Study
Enquiries: ias@ust.hk / 2358 5912
http://ias.ust.hk
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