Program Schedule

Updated as 13 Mar 2018

Venue: IAS2042, 2/F, Lo Ka Chung Building, Lee Shau Kee Campus, HKUST

19 Mar | 20 Mar | 21 Mar | 22 Mar | 23 Mar

19 Mar (Mon)

Time Event
09:00-09:10 Opening Remarks
Andrew G Cohen
(Director of the HKUST Jockey Club Institute for Advanced Study)
Structure of Transcriptional Machinery
Session Chair: Robert Landick (University of Wisconsin-Madison)
09:10-09:50 "Architecture of the RNA Polymerase II Elongation Complex with Basal Elongation Factors"
Shunichi Sekine (RIKEN)
09:50-11:00 Coffee Break (Open Area outside the Seminar Room)
11:00-11:40 "Structural Basis of RNA Polymerase I Transcription"
Christoph Engel (University of Regensburg and Max Planck Institute for Biophysical Chemistry)
11:40-12:20 "Inhibiting the Mycobacteria RNAP"
Elizabeth Campbell (The Rockefeller University)
12:20-14:00 Welcome Lunch at the Conference Lodge (By invitation only)
Mechanism and Regulation of Initiation
Session Chair: Dong Wang (University of California at San Diego)
14:00-14:40 "Structural Basis of RNA Polymerase I Activation and Hibernation"
Carlos Fernández Tornero (Centro de Investigaciones Biológicas)
14:40-15:20 "Promoter Opening by Bacterial RNA Polymerase - One Step at a Time"
Seth Darst (The Rockefeller University)
15:20-15:50 Coffee Break (Open Area outside the Seminar Room)
15:50-16:30 "Structural Basis of Reiterative Transcription by Bacterial RNA Polymerase"
Katsuhiko Murakami (Pennsylvania State University)
16:30-17:10 "Molecular Dynamics Simulations of RNA Polymerase II to Understand Determinants of Fidelity and Function"
Michael Feig (Michigan State University)

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20 Mar (Tue)

Time Event
Mechanism and Regulation Elongation, Catalysis, and Fidelity
Session Chair: Elizabeth Campbell (The Rockefeller University)
09:00-09:40 "Sequence-dependent Control of RNA Polymerase Translocation"
Georgi Belogurov (University of Turku)
09:40-10:20 "Roles of a Half-translocated Intermediate, RNAP Swiveling, and Nascent RNA Structure in Transcriptional Pausing"
Robert Landick (University of Wisconsin-Madison)
10:20-10:50 Coffee Break (Open Area outside the Seminar Room)
10:50-11:30 "Mechanism of RfaH Anti-pausing and Antitermination"
Irina Artsimovitch (Ohio State University)
11:30-12:10 "Quantitative Analysis of the Transcription Accuracy of RNA Polymerase II via a Multi-scale Approach Tightly Integrating Simulation and Experiment"
Xuhui Huang (The Hong Kong University of Science and Technology)
12:10-14:00 Lunch Break
Transcription on Chromatin
Session Chair: Toyotaka Ishibashi
(The Hong Kong University of Science and Technology)
14:00-14:40 "Architecture of Pol II(G) and Molecular Mechanism of Transcription Regulation by Gdown1"
Robert Roeder (The Rockefeller University)
14:40-15:20 "Post-initiation Functions of the Mediator Complex"
Joan Conaway (Stowers Institute for Medical Research)
15:20-15:50 Coffee Break (Open Area outside the Seminar Room)
15:50-16:30 "Structure and Dynamics of the Chromatin Fiber in Gene Regulation"
Guohong Li (Institute of Biophysics, Chinese Academy of Sciences)
16:30-17:10 "How Does a Viral RNA Polymerase Ratchet along DNA without Possibly Backtracking?"
Jin Yu (Beijing Computational Science Research Center)
18:00-20:30 Dinner Banquet (By invitation only)

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21 Mar (Wed)

Time Event
Interface between Transcription and DNA Repair
Session Chair: Irina Artsimovitch (Ohio State University)
09:00-09:40 "Ubiquitylation and Degradation of RNA Polymerase II"
Jesper Svejstrup (The Francis Crick Institute)
09:40-10:20 "CSA and CSB Regulators of Transcription Arrest"
Jean-Marc Egly (Institut de Génétique et Biologie Moléculaire et Cellulaire)
10:20-11:00 Group Photo Session and Coffee Break
(Open Area outside the Seminar Room)
11:00-11:40 "Molecular Basis of Lesion Recognition for Transcription Coupled Repair"
Dong Wang (University of California at San Diego)
11:40-12:20 "Rescuing Arrested RNA Polymerase"
Terence Strick (Centre National de la Recherche Scientifique)
12:20- Free Time

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22 Mar (Thu)

Time Event
Genome Approach and Beyond
Session Chair: Ron Conaway (Stowers Institute for Medical Research)
09:00-09:40 "How Specific Factors Collaborate to Regulate of Distinct Steps in the Transcription Cycle"
John Lis (Cornell University; Visiting Professor of HKUST Jockey Club Institute for Advanced Study)
09:40-10:20 "Genomic Mechanisms of Gene Regulation and Chromatin Organization"
Frank Pugh (Pennsylvania State University)
10:20-10:50 Coffee Break (Open Area outside the Seminar Room)
10:50-11:30 "RNA Polymerase II Dynamics and Its Enigmatic CTD"
Dave Gilmour (Pennsylvania State University)
11:30-12:10 "R-loop Formation and Transcriptional Control"
Xiang-dong Fu (University of California at San Diego)
12:10-14:00 Lunch Break
Genome Approach and Beyond
Session Chair: Xuhui Huang (The Hong Kong University of Science and Technology)
14:00-14:40 "Single-Molecule Measurements Reveal the Dynamics and Force Dependency of Archaeal Transcription"
Dina Grohmann (University of Regensburg)
14:40-15:20 "The Regulation Mechanism of Mitochondrial RNA Polymerase Transcription Elongation"
Toyotaka Ishibashi (The Hong Kong University of Science and Technology)
15:20-16:00 "Simultaneous Mapping of Transcript Start and End Sites across the Bacterial Transcriptome"
Shixin Liu (The Rockefeller University)
16:00-16:30 Coffee Break (Open Area outside the Seminar Room)

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23 Mar (Fri)

Time Event
09:00-10:00 Discussion Session
10:00-10:30 Coffee Break (Lobby, G/F)
10:30-12:00 IAS Distinguished Lecture - "Transcriptional Regulatory Mechanisms in Animal Cells" [Abstract]
Robert Roeder (The Rockefeller University)
Venue: IAS Lecture Theater, G/F
12:00-14:00 Lunch Break
14:00-15:30 IAS Distinguished Lecture - "The Mediator Complex in Transcriptional Regulation" [Abstract]
Joan Conaway (Stowers Institute for Medical Research)
Venue: IAS Lecture Theater, G/F
15:30-16:00 Coffee Break (Lobby, G/F)

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